Keflex is a cephalosporin antibiotic used to treat bacterial infections. The active ingredient in Keflex is cephalexin which is dispensed as oral capsules (250mg, 333mg, 500mg and 750mg) and a pediatric oral solution.
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Keflex (Cephalexin)

Keflex is a cephalosporin antibiotic drug that helps in the treatment of bacterial infections. It fights the bacterial infections of the body like ear infection, urinary tract infection, upper respiratory tract infection or skin infection.

The generic name of Keflex is Cephalexin.

Indications of Keflex (Cephalexin)

Keflex (Cephalexin) is considered a potent drug for the treatment of bacterial infections. The indications of this cephalosporin drug include:

  • Respiratory Tract Infection

It is used in the treatment of respiratory tract infections caused by Streptococcus pyogenes and Streptococcus pneumonia.

  • Skin and Skin Structure Infections

It is used in the treatment of skin and skin structure infections that are caused by the gram- positive bacteria like Streptococcus pyogenes and Staphylococcus aureus.

  • Otitis Media

It is used in the treatment of otitis media caused due to Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenza.

  • Bone Infections

It is used for bone infections caused due to Proteus mirabilis and Staphylococcus aureus.

  • Genitourinary Tract Infections

It is used for the treatment of genitourinary tract infections like acute prostatitis caused due to Klebsiella pneumonia, Proteus mirabilis, and Escherichia coli.

Keflex (Cephalexin) tablets

Side- effects of Keflex (Cephalexin)

The serious side- effect of Keflex (Cephalexin) include:

  • Allergic reaction to Keflex (Cephalexin) manifesting as difficult breathing, occurrence of hives or rashes and swelling on face, throat, lips and tongue
  • Watery or bloody diarrhea
  • Severe pain in stomach
  • Yellowing of eyes or skin (jaundice)
  • Little or no urination at all
  • Easy bruising and unusual bleeding from rectum, nose, vagina and mouth, occurrence of red or purple pinpoint spots beneath the skin
  • Hallucination, confusion, agitation
  • Severe skin reaction manifesting as fever, swelling on tongue or face, sore throat, burning in eyes, pain in skin followed by the occurrence of purple or red skin rashes spreading to upper body and face and causing blistering as well as peeling

The common side- effects caused by Keflex (Cephalexin) include:

  • Diarrhea
  • Feeling tired
  • Dizziness
  • Joint pain
  • Headache
  • Vaginal itching or discharge

How to take Keflex (Cephalexin)?

You must take Keflex (Cephalexin) as suggested by your doctor. Take it in the exact dose as prescribed by the doctor. Do not change the quantity of single dose and duration of taking the drug as recommended by the doctor.

For adults and pediatric patients who are of 15 years, the recommended dose is 250 mg in every six hours, but, it can also be taken as a dose of 500 mg in every 12 hours.

For pediatric patients who are more than one year of age, the recommended dose of Keflex (Cephalexin) is 25 to 50 mg per kg. It is given in divided doses for seven to fourteen days. For severe infection, 50 to 100 mg per kg of dose is given regularly in divided doses.

For otitis media, daily dose of 75 to 100 mg per kg is given in divided doses.

Pregnancy and Breastfeeding

You must take Keflex (Cephalexin) in pregnancy only of it is strictly recommended by the doctor.

If you are nursing mother, you must discuss the potential side- effects with your doctor as this drug is released into breast milk.

Drug Uses

Keflex is prescribed to treat upper respiratory infections, reproductive infections, skin infections, bone infections, urinary tract infections and ear infections, all of which are caused by bacteria.

Keflex is used to treat other medical conditions not listed in this information guide.

Keflex is not used to treat viral infections.


Keflex must always be used as directed. Do not make adjustments to the dose before speaking to a doctor. Keflex does not need to be taken with food, but if stomach irritations occur, it is advisable to take further doses with meals.

If using the oral solution shake the bottle well before use. Use a proper medical measuring device to ensure that the correct dose is administered.

Missed Dose

If you miss a dose, it may be taken when you remember. However, do not take the missed dose near the time of the next scheduled dose. In this case, ignore the missed dose. Never double-up on a dose.

Warnings and Precautions

Do not use Keflex if you are allergic to cephalexin.

Tell your doctor if you are allergic to penicillin, or suffer with any of the following: intestinal or stomach disorders, liver or kidney disease, or malnutrition.

Before using Keflex, you must give your doctor full details of your medical history and other medications that you use. These include herbal medicines and vitamin supplements. Keflex can react badly with some medications.

Keflex oral solution may contain sugar – if you have diabetes discuss this with your doctor.

Keflex is not likely to harm an unborn fetus therefore women who are pregnant are able to use this drug. Keflex is passed into breast milk so women who are breast-feeding should use Keflex with caution as directed by a doctor.

Antibiotics have been known to cause diarrhea – this can often be an indication of a secondary infection. Contact your doctor immediately if your stools are watery or bloody.

Possible Side-effects

Call for emergency assistance if any of the following symptoms of allergy occur: difficulty in breathing, hives, or swelling of the lips, tongue, throat or face.

Contact your doctor immediately if any of the following side-effects occur: convulsions, sore throat, bloody or watery diarrhea, fever, skin rash (with peeling or blistering), jaundice, confusion, weakness, dark colored urine, weakness, agitation, hallucinations, decreased urination, easy bruising, or easy bleeding.

Less serious side-effects can include fatigue, mild nausea, diarrhea, vomiting, joint pain, or vaginal discharge or itching. These side-effects generally occur in the initial stages of treatment and do not last long.

Contact your doctor if any uncomfortable symptoms occur, or persist.


Call for emergency help immediately. Symptoms of overdose can include stomach pain, vomiting or nausea, bloody urine, or diarrhea.

Storage instructions

Keflex must be kept away from children and stored in a dry, cool place away from sunlight and moisture.