Allopurinol is a xanthine oxidase inhibitor that decreases the production of uric acid. Allopurinol is dispensed as oral tablets (100mg and 300mg).
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Allopurinol is sold under the brand name of alloprim, lopurin and zyloprim. It decreases the uric acid production in the body. The buildup of uric acid may be responsible for kidney stones or gout.


Allopurinol is used for the treatment of kidney stones/gout, and to reduce the uric acid levels in those patients who are undergoing the treatment for cancer.

How to Use

Take allopurinol precisely as endorsed by your specialist. Try not to take in bigger or littler sums or for longer than prescribed. Take after the headings on your solution mark.

Your specialist may once in a while change your measurement to ensure you get the best outcomes.

Bring each measurement with a glass full of water. To lessen your danger of kidney stones framing, drink 8 to 10 full glasses of liquid consistently, unless your specialist discloses to you generally. You may have gout attacks all the more regularly when you initially begin taking allopurinol. Your specialist may prescribe other gout drug to be consumed along with allopurinol. Continue utilizing your drug as coordinated and tell your specialist if your side effects don't improve following a couple of months of treatment.

Allopurinol 300mg tablets USP

Side Effects

Avoid the use of allopurinol and inform your doctor right away if you have a severe after effect like:

  • fever,
  • severe skin blistering,
  • headache
  • skin peeling,
  • sore throat,
  • red skin rash;
  • pain or trouble while urinating;
  • blood in urine
  • nausea,
  • loss of appetite,
  • upper stomach pain,
  • itching,
  • weight loss,
  • clay-colored stools,
  • joint pain,
  • dark urine,
  • jaundice
  • No or less urination than usual
  • flu symptoms;
  • muscle weakness; or
  • severe tingling,
  • easy bruising,
  • pain,
  • numbness,
  • unusual bleeding (mouth, nose, rectum or vagina),
  • purple/red spots on your skin.

Less serious side effects of allopurinol are as follows:

  • vomiting,
  • headache;
  • diarrhea;
  • variation in your sense of taste;
  • drowsiness,
  • Muscle pain.


The count of blood cells can be reduced because of this drug. These blood cells help to fight against infections in the body.

Don’t drink alcohol during the intake of this medicine. It can worsen your condition in a very bad manner. Allopurinol may be responsible for the impairment of your thinking abilities or reactions. Drive carefully.

Don’t take zyloprim if you are hypersensitive to it.

To ensure that this drug is safe for your use, let your doctor know if you have any of the following medical conditions:

  • kidney disease;
  • diabetes;
  • liver disease;
  • high blood pressure; or
  • congestive heart failure;
  • if you are undergoing any chemotherapy.

Pregnancy and Allopurinol

Whether allopurinol has the ability to harm an unborn child, it is yet unknown. Let your doctor know if you are pregnant during the intake of this drug. Allopurinol can penetrate into maternal milk and may cause damage to a nursing baby. Avoid breast feeding during the intake of this medicine.

Drug Uses

Allopurinol is used to treat kidney stones and gout. It is also used to reduce uric acid in patients who are undergoing treatment for cancer. Allopurinol works by decreasing the production of uric acid in the body.

Allopurinol is used to treat other medical conditions not listed in this information guide.


Allopurinol must always be used as directed. Do not make adjustments to the dose before speaking to a doctor. Allopurinol should be taken with water. During treatment with this drug, it is important to increase your daily intake of fluids, especially water.

Missed Dose

If you miss a dose, it may be taken when you remember. However, do not take the missed dose near the time of the next scheduled dose. In this case, ignore the missed dose. Never double-up on a dose.

Warnings and Precautions

Do not use this drug if you are allergic to allopurinol.

Tell your doctor if you are undergoing chemotherapy, or if you suffer with any of the following: diabetes, liver or kidney disease, high blood pressure, or congestive heart failure.

Allopurinol may affect the immune system. This can make you more susceptible to illnesses and infections. It is therefore recommended that while using Allopurinol your blood is regularly tested.

Avoid the use of alcohol while taking Allopurinol. When alcohol is taken with this drug, concentration and reactions may be impaired. Avoid driving or doing other dangerous activities during treatment with Allopurinol.

Allopurinol may harm an unborn fetus, so women who are pregnant or planning to become pregnant should inform their doctor. Allopurinol is passed into breast milk therefore women who are breast-feeding should use this drug with caution, under directions of a doctor.

Before using Allopurinol, you must give your doctor full details of your medical history and other medications that you use. These include herbal medicines and vitamin supplements. Allopurinol can react badly with some medications.

Possible Side-effects

Call for emergency assistance if any of the following symptoms of allergy occur: difficulty in breathing, hives, or swelling of the lips, tongue, throat or face.

Contact your doctor if any of the following side-effects occur: decreased urination, bloody or painful urination, skin rash (even if it is mild), fever, headache, sore throat, skin rash with peeling or blistering, easy bruising, muscle weakness, tingling or numbness, fever, body aches, chills, flu symptoms, jaundice, or convulsions.

Less serious side-effects can include vomiting or nausea, drowsiness, dizziness, joint pain, diarrhea, or sweating. These side-effects generally occur in the initial stages of treatment and do not last long.

Contact your doctor if any uncomfortable symptoms occur, or persist.


Overdose with Allopurinol is not likely to be life-threatening. However, if overdose is suspected, call for emergency assistance.

Storage instructions

Allopurinol must be kept away from children and stored in a dry, cool place away from sunlight and moisture.